While it is true that there are some antioxidants that can hinder chemotherapy’s effects, recent research suggests that there are some antioxidants that, when combined with chemotherapy, can increase the effectiveness of treatment by upwards of 30%. In this article, we seek to provide some clarity on this topic by providing useful guidelines that patients and health care providers can use to make better, more informed treatment decisions. Although this article specifically focuses on advanced metastatic prostate cancer, future articles will focus on the use of antioxidants and chemotherapy in the treatment of other cancers.